Amitriptyline and heart block.
نویسندگان
چکیده
منابع مشابه
Block of human heart hH1 sodium channels by amitriptyline.
Amitriptyline is a tricyclic antidepressant used to treat major depression and various neuropathic pain syndromes. This drug also causes cardiac toxicity in patients with overdose. We characterized the tonic and use-dependent amitriptyline block of human cardiac (hH1) Na(+) channels expressed in human embryonic kidney cells under voltage-clamp conditions. Our results show that, near the therape...
متن کاملHyperkalemia-induced complete heart block
Background: Potassium, as an extracellular ion, plays an important role in the electrophysiologic function of the myocardium and any change in extracellular concentration of this ion might have a marked impression upon myocyte electrophysiologic gain. High serum potassium levels are thought to impair pulse conduction in Purkinje fibers and ventricles more than that in the Atrio...
متن کاملhyperkalemia-induced complete heart block
background: potassium, as an extracellular ion, plays an important role in the electrophysiologic function of the myocardium and any change in extracellular concentration of this ion might have a marked impression upon myocyte electrophysiologic gain. high serum potassium levels are thought to impair pulse conduction in purkinje fibers and ventricles more than that in the atrioventricular (av) ...
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متن کاملParoxysmal Heart Block in Bundle Branch Block.
When a patient is suspected of having Stokes-Adams disease the electrocardiogram is of critical importance, particularly in respect of the auriculo-ventricular (A-V) conduction time. Should this not be prolonged, the possibility of paroxysmal heart block remains, although the diagnosis of Stokes-Adams disease is uncertain without some degree of heart block recorded graphically. It is not known ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1967
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5560.311-a